Reyes has five sisters including a twin sister named Joselin who played a paramedic on Law & Order: Special Victims Unit. She is the cousin of Artist/Model Viancey. She attended Hunter College in Manhattan, where her acting career started out. She was married to writer/director Edwin M. Figueroa for 11 years before they divorced. Reyes and her boyfriend George Valencia have a daughter, Leila Rey, born on November 27, 2009. Reyes resided in Los Angeles during Scrubs production, and frequently returns to her native New York. In September 2006, she fractured her hip in a fall, which affected filming of the Scrubs episode "My Musical".